METHOD Recording the ECG of mice in different time after they were admistrated with astemizole in different dose in different time.
方法用不同剂量的阿司咪唑对小鼠灌胃,分别记录不同时间的心电图变化。
CONCLUSION: the effect of cetirizine in treating perennial allergic rhinitis is faster and the adverse reaction is less than those of astemizole.
结论:西替利嗪治疗常年变应性鼻炎与阿司咪唑比较具有起效快、不良反应少的特点。
RESULTS astemizole could slower the heart rate of mice, prolong P-R and Q-T interphase, even arise the complete AV block and sinus beat stop with the dose increase.