Adapalene was synthesized from 4-bromophenol by alkylation, etherification, condensation and hydrolysis with an overall yield of 51%.
对溴苯酚经烷基化、硫酸二甲酯醚化、缩合及水解反应制得阿达帕林,总收率51%。
Content of the products were quantitatively determined by two-phase chemical titration using bromophenol blue as the indicator and dichloroethane as the phase splitting agent.
以溴酚蓝为指示剂、二氯乙烷为分散相两相化学滴定法测定产物的含量。
The bromophenol compounds of the invention have inhibitory activity against protein tyrosine phosphatase (PTP1B), and can be used for treating the type 2 diabetes and the obesity.