Methods Apraclonidine was synthesized from P-Nitraniline by reaction with reduction, adding protection group, formylation, chlorination, cyclization, off-protecting group.
方法采用对硝基苯胺为原料,经还原、加保护基、甲酰化、氯化、环合、脱保护基六步反应法可进行化学合成。
Also the optimum reaction conditions including formylation, method and reaction time of cyclization were studied to enhance the yield. In the end, their fluorescence spectrum are analyzed.