The entropy effect on the Gibbs free energy of 7-thioguanine base is very small and there is little significance for the tautomeric equilibria of the base.
硫代鸟嘌呤互变异构的熵效应小,对互变异构平衡没有显著的影响,而焓变对互变异构产生了主要的影响。
Mercaptopurine has been a standard component of long-term continuing treatment for childhood lymphoblastic leukaemia, whereas 6-thioguanine has been mainly used for intensification courses.